WISP3 (CCN6) IS A SECRETED TUMOR-SUPPRESSOR PROTEIN THAT MODULATES IGF SIGNALING IN INFLAMMATORY BREAST CANCER

WISP3 (CCN6) Is a Secreted Tumor-Suppressor Protein that Modulates IGF Signaling in Inflammatory Breast Cancer

Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer.We have found that WISP3 is lost in 80% of human IBC tumors and that it has growth- and angiogenesis-inhibitory functions in breast cancer in vitro and in vivo.WISP3 is a cysteine-rich, putatively secreted protein that belongs to the CCN family.It contains a

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A self-healing and bioactive coating based on duplex plasma electrolytic oxidation/polydopamine on AZ91 alloy for bone implants

Magnesium (Mg) alloys are well-known in biomedical materials owing to their elastic module near to bone, biocompatibility and biodegradation properties.Nevertheless, poor corrosion resistance hinders their biomedical applications.Besides, it is necessary to endow Mg alloys with bioactive property, which is crucial for temporary bone Condom implants

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